Urinary miRNAs measured in rat studies associated with nephron-specific chemical toxicity

Description

Urine samples were derived from a variety of archived industry-led studies, outlined in the dataset. The purpose was to measure a targeted set of miRNA targets that were represented in the Thermo Fisher TLDA A and TLDA B card sets in Figure 2. These case studies were selected due to probable nephrotoxicity, associated with published or internal records. These clinical markers and histopath evidence was included in Table 1 associated dataset. Given specific nephron toxicity, this experiment would determine miRNA candidates that may be specific toxicity biomarkers. This analysis set up the Venn Analysis in Figure 3, which specified candidates for nephron-specific analyses. This dataset is associated with the following publication: Chorley, B., H. Ellinger-Ziegelbauer, M. Tackett, F. Simutis, A. Harrill, J. McDuffie, E. Atabakhsh, R. Nassirpour, L. Whiteley, J. Léonard, G. Carswell, E. Harpur, C. Chen, and J. Gautier. Urinary miRNA Biomarkers of Drug-Induced Kidney Injury and Their Site Specificity Within the Nephron. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 180(1): 1-16, (2021).

Resources

Name Format Description Link
53 Data%20associated%20with%20Fig%202%20and%20Table%202.xlsx https://pasteur.epa.gov/uploads/10.23719/1518921/Data%20associated%20with%20Fig%202%20and%20Table%202.xlsx
53 Data%20associated%20with%20Table%201.xlsx https://pasteur.epa.gov/uploads/10.23719/1518921/Data%20associated%20with%20Table%201.xlsx
53 Data%20associated%20with%20Fig%203.xlsx https://pasteur.epa.gov/uploads/10.23719/1518921/Data%20associated%20with%20Fig%203.xlsx

Tags

  • biomarkers
  • safety-assessment
  • kidney-injury
  • micrornas

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