The role of dorsal third ventricle α2 adrenergic antagonism or glucocorticoid antagonism in modulating the neuroendocrine stress response to acute ozone exposure
Description
Dorsal third ventricle infusions of the alpha 2 adrenergic receptor antagonist, mianserin- which increases brain concentrations of dopamine, serotonin, and acetylcholine, or the glucocorticoid receptor antagonist, mifepristone, were performed in male WKY rats prior to acute ozone exposure at 0.8 ppm for 4 hours. This experiment was designed to target hippocampal and hypothalamic neuromodulation to determine the role of indoleamines, monoamines, and glucocorticoids in mediating the systemic and pulmonary effects to ozone exposure.
Resources
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Description |
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WKYICV-KR2024%20Science%20Hub%20Mianserin%20and%20Mife%20Manuscript%20Updated%206.9.25.xlsx |
https://pasteur.epa.gov/uploads/10.23719/1532349/WKYICV-KR2024%20Science%20Hub%20Mianserin%20and%20Mife%20Manuscript%20Updated%206.9.25.xlsx |
Tags
- pulmonary-injury
- neuroendocrine-stress-axes
- ozone
- air-pollution
- monoamines
- catecholamines
- glucocorticoids