The contribution of the neuroendocrine system to adaption after repeated daily ozone exposure in rats

Description

we hypothesized that ozone-adaptation is linked to diminution of neuroendocrine stress-axes activation and glucocorticoid levels. Male Wistar-Kyoto-rats (12-week-old) were injected with vehicle or a therapeutically-relevant dexamethasone dose (0.01-mg/kg/day; intraperitoneal) for 1-month to determine if suppression of glucocorticoid signaling was linked to adaptation. Vehicle- and dexamethasone-treated rats were exposed to air or 0.8-ppm ozone, 4 hours/dayx2 or 4 days to assess the impacts of acute exposure and adaptation, respectively. This dataset is associated with the following publication: Heinriquez, A., S. Snow, J. Dye, M.C. Schladweiler, D. Alewel, C. Miller, and U. Kodavanti. The contribution of the neuroendocrine system to adaption after repeated daily ozone exposure in rats. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 447(116085): 1, (2022).

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Name Format Description Link
53 Science%20Hub%20Version%20To%20Urmila%2006%2006%202022.xlsx https://pasteur.epa.gov/uploads/10.23719/1528281/Science%20Hub%20Version%20To%20Urmila%2006%2006%202022.xlsx

Tags

  • stress-hormones
  • adaptation
  • nitrogen-and-co-pollutants
  • neuroendocrine
  • ozone

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