Targeted RNA-sequencing of aged FFPE liver tissue data

Description

Gene expression data on >20 year-old, paired frozen and archival FFPE liver samples generated using targeted resequencing (TempO-Seq) and whole-genome RNA-sequencing methods. Samples were originally collected from male mice exposed to a reference chemical (dichloroacetic acid, DCA) at 0, 198, 313 and 427 mg/kg-day, (n=6/dose) by drinking water for 6 days. Portions of this dataset are inaccessible because: Including all of these files on ScienceHub would exceed the 1 Gb limit. They can be accessed through the following means: The data is stored on the L: Drive. Information on all of the files and file paths are indicated in the 20210923_Readme.xlsx file uploaded with the data. Format: Excel files, tab delimited files, csv files, and sequencing FASTQ files. This dataset is associated with the following publication: Cannizzo, M., C. Wood, S. Hester, and L. Wehmas. Case study: Targeted RNA-sequencing of aged formalin-fixed paraffin-embedded samples for understanding chemical mode of action. Toxicology Reports. Elsevier B.V., Amsterdam, NETHERLANDS, 9: 883-894, (2022).

Resources

Name Format Description Link
0 https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE78962
53 20210923_Readme.xlsx https://pasteur.epa.gov/uploads/10.23719/1523143/20210923_Readme.xlsx
53 20210908_DCA9402_Additional_Data.xlsx https://pasteur.epa.gov/uploads/10.23719/1523143/20210908_DCA9402_Additional_Data.xlsx
53 20210908_DCA9402_MS_tables.xlsx https://pasteur.epa.gov/uploads/10.23719/1523143/20210908_DCA9402_MS_tables.xlsx

Tags

  • formalin-fixed-paraffin-embedded-ffpe
  • benchmark-dose-analysis
  • rna-sequencing
  • dichloroacetic-acid

Topics

Categories