Description
Background
The continuous spread of penicillin-resistant pneumococci represents a permanent threat in the treatment of pneumococcal infections, especially when strains show additional resistance to quinolones. The main objective of this study was to determine a treatment modality impeding the emergence of quinolone resistance.
Results
Exposure of a penicillin-resistant pneumococcus to increasing concentrations of trovafloxacin or ciprofloxacin selected for mutants resistant to these drugs. In the presence of sub-inhibitory concentrations of vancomycin, development of trovafloxacin-resistance and high-level ciprofloxacin-resistance were prevented.
Conclusions
Considering the risk of quinolone-resistance in pneumococci, the observation might be of clinical importance.
Resources
| Name | Format | Description | Link |
|---|---|---|---|
| Official Government Data Source | HTML | Visit the original government dataset for complete information, documentation, and data access. | Open resource |