Structural Malformations in Brain Accompany Developmental Perchlorate Exposure in Rodents

Description

Structural defects in the rat brain associated with maternal exposure to ammonium perchlorate accompanied reductions in circulating levels of thyroid hormone in the dam and the fetus. The magnitude of the effect was small relative to other thyroid hormone disruptors, but his was due to the lack of sufficient bioavailability of perchlorate to the nursing neonate. When pups were administered perchlorate directly for the first 6 days of life or if perchlorate was administered under conditions of maternal dietary iodine deficiency, very large brain malformations were induced. This dataset is associated with the following publication: Gilbert, M., K. O'Shaughnessy, K. Bell, and J. Ford. Structural Malformations in the Neonatal Rat Brain Accompany Developmental Exposure to Ammonium Perchlorate. Toxics. MDPI, Basel, SWITZERLAND, 11(12): 1027, (2023).

Resources

Name Format Description Link
53 ScienceHub%20Dev%20DirectDose%20IDPer%20PVH.xlsx https://pasteur.epa.gov/uploads/10.23719/1531741/ScienceHub%20Dev%20DirectDose%20IDPer%20PVH.xlsx

Tags

  • in-vivo
  • environmental-justice
  • developmental-neurotoxicity
  • endocrine-disrupting-chemicals
  • childrens-environmental-health
  • thyroid
  • adverse-outcome-pathways-aops

Topics

Categories