Sample size requirements for case-control study designs

Description

Background Published formulas for case-control designs provide sample sizes required to determine that a given disease-exposure odds ratio is significantly different from one, adjusting for a potential confounder and possible interaction. Results The formulas are extended from one control per case to F controls per case and adjusted for a potential multi-category confounder in unmatched or matched designs. Interactive FORTRAN programs are described which compute the formulas. The effect of potential disease-exposure-confounder interaction may be explored. Conclusions Software is now available for computing adjusted sample sizes for case-control designs.

Resources

Name Format Description Link
21 Visit the original government dataset for complete information, documentation, and data access. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC61037/

Tags

  • nih
  • sample-size
  • study-design
  • odds-ratio
  • case-control-studies

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