Pulmonary and Vascular Effects of Acute Ozone Exposure in Diabetic Rats Fed an Atherogenic Diet
Description
In this study, we investigated effects of inhaled ozone exposure and high-cholesterol diet (HCD) in healthy Wistar and Wistar-derived Goto-Kakizaki (GK) rats, a non-obese model of type 2 diabetes. Male rats (4-week old) were fed normal diet or HCD for 12 weeks and then exposed to filtered air or 1.0 ppm ozone (6hrs/day) for 1 or 2 days. We examined pulmonary, vascular, hematology, and inflammatory responses after each exposure plus an 18-hr recovery period.
This dataset is associated with the following publication:
Snow, S., A. Henriquez, L. Thompson, C. Fisher, M.C. Schladweiler, C. Wood, and U. Kodavanti. Pulmonary and Vascular Effects of Acute Ozone Exposure in Diabetic Rats Fed an Atherogenic Diet. TOXICOLOGY AND APPLIED PHARMACOLOGY. Academic Press Incorporated, Orlando, FL, USA, 415(115430): 1, (2021).
Resources
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Description |
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53 |
GK-ozone%20Pulmonary%20Paper%20Science%20Hub-final.xlsx |
https://pasteur.epa.gov/uploads/10.23719/1521140/GK-ozone%20Pulmonary%20Paper%20Science%20Hub-final.xlsx |
Tags
- type-2-diabetes-rat-model
- pulmonary-injury
- systemic-inflammation
- vasocontraction
- western-high-cholesterol-diet