Predicting Potential Human Health Risk with the Tox21 10k Library

Description

This study represents the first report applying IVIVE approaches and exposure comparisons using the entirety of the Tox21 federal collaboration chemical screening data, incorporating assay response efficacy and quality of concentration-response fits, and providing quantitative anchoring to first address the likelihood of human in vivo interactions with Tox21 compounds. This likelihood was assessed using a maximum blood concentration to in vitro response ratio approach (Cmax/AC50), analogous to decision-making methods for clinical drug-drug interactions. Fraction unbound in plasma (fup) and intrinsic hepatic clearance (CLint) parameters were estimated in silico and incorporated in a 3-compartment toxicokinetic (TK) model to first predict Cmax for in vivo corroboration using therapeutic scenarios. This dataset is associated with the following publication: Sipes, N., J. Wambaugh, R. Pearce, S. Auerbach, B. Wetmore, J. Hsieh, A. Shapiro, D. Sboboda, M. DeVito, and S. Ferguson. (ENVIRONMENTAL SCIENCE and TECHNOLOGY) An Intuitive Approach for Predicting Human Risk with the Tox21 10k Library. ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, issue}: 10786-10796, (2017).

Resources

Name Format Description Link
33 Supporting%20Information_EST_FINAL_18JUL2017.pdf https://pasteur.epa.gov/uploads/10.23719/1395143/Supporting%20Information_EST_FINAL_18JUL2017.pdf
53 Table%20S1.xlsx https://pasteur.epa.gov/uploads/10.23719/1395143/Table%20S1.xlsx
53 Table%20S2.xlsx https://pasteur.epa.gov/uploads/10.23719/1395143/Table%20S2.xlsx
53 Table%20S3.xlsx https://pasteur.epa.gov/uploads/10.23719/1395143/Table%20S3.xlsx
0 https://ntp.niehs.nih.gov/sandbox/ivive/

Tags

  • tox21
  • httk
  • ivive
  • high-throughput-toxicokinetics
  • exposure
  • high-throughput-screening
  • hts
  • expocast
  • in-vitro-to-in-vivo-extrapolation-ivive

Topics

Categories