Patent AT-E401416-T1: [Translated] METHOD FOR PRODUCING OPTICALLY ACTIVE N-PROTECTED PROPARGYLGLYCINE
Description
A method for producing (S)-N-protected-propargylglycine of the following formula (2), which comprises asymmetrically hydrolyzing an N-protected-propargylglycine of the following formula (1): nwherein R 1 represents an alkyl group having 1 to 4 carbon atoms, R 2 and R 3 each independently represent a hydrogen atom or a protective group of an amino group, R 2 and R 3 being not simultaneously a hydrogen atom, and a carbon atom appended with a mark * represents an asymmetric carbon atom, nusing an asymmetric hydrolysis enzyme derived from a microorganism selected from Thermomyces genus, Aspergillus genus, Rhizopus genus, Penicillium genus, Pseudomonas genus, Humicola genus, Burkholderia genus, Candida genus and Streptomyces genus, or a cultured substance of a microorganism having an ability of producing this enzyme or a treated substance thereof, nor using an asymmetric hydrolysis enzyme which is ±-amylase derived from a microorganism selected from Bacillus subtilis and Bacillus licheniformis.
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Access the complete Patent AT-E401416-T1: [Translated] METHOD FOR PRODUCING OPTICALLY ACTIVE N-PROTECTED PROPARGYLGLYCINE on the official website. |
https://pubchem.ncbi.nlm.nih.gov/patent/AT-E401416-T1 |
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- pubchem