Patent AT-E401394-T1: [Translated] IMPROVED DNASE LIQUID SOLUTIONS
Description
The present invention relates to the use of calcium ion and/or sugars to minimize thermal aggregation of DNase and to the use of calcium ion to stabilize liquid solutions of DNase, the solutions having a pH of less than neutral. DNase is the active pharmaceutical principle and the solutions may contain other pharmaceutically acceptable excipients making them suitable for pharmaceutical administration. In the first instance, calcium ion/sugar minimizes the effects of thermal aggregation in the solution. In the second aspect, calcium ion stabilizes the lower pH solutions from protein precipitation.
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Access the complete Patent AT-E401394-T1: [Translated] IMPROVED DNASE LIQUID SOLUTIONS on the official website. |
https://pubchem.ncbi.nlm.nih.gov/patent/AT-E401394-T1 |
Tags
- patent
- chemistry
- research
- innovation
- pubchem