Patent AT-E401348-T1: [Translated] IMMUNOCONJUGATES WITH HIGH BINDING AFFINITY
Description
Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and immunoconjugates employing them. Also described are diagnostic and therapeutic methods using the antibodies. The anti-mesothelin antibodies are well-suited for the diagnosis and treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.
Resources
| Name |
Format |
Description |
Link |
|
21 |
Access the complete Patent AT-E401348-T1: [Translated] IMMUNOCONJUGATES WITH HIGH BINDING AFFINITY on the official website. |
https://pubchem.ncbi.nlm.nih.gov/patent/AT-E401348-T1 |
Tags
- patent
- chemistry
- research
- innovation
- pubchem