Patent AT-E401319-T1: [Translated] SUBSTITUTED 2-(2,6-DIOXOPIPERIDINE-3-YL)-PHTHALIMIDES AND METHOD FOR REDUCING TNF-ALPHA LEVELS

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1. A 2,6-dioxopiperidine selected from the group consisting of n( a ) a compound of the formula: nin which: none of X and Y is C=O and the other of X and Y n( i ) each of R 1 , R 2 , R 3 , and R 4 , independently of yl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms or ( ii ) one of R 1 , R 2 , R 3 , and R 4 is -NHR 5 and the remaining of R 1 , R 2 , R 3 , and R 4 are hydrogen; nR 5 is hydrogen, alkyl of 1 to 8 carbon atoms, or CO-R 7 -CH(R 10 )NR 8 R 9 ; nR 6 is hydrogen, alkyl of 1 to 8 carbon atoms, benzo, chloro, or fluoro; nR 7 is m -phenylene or p -phenylene or -(C n H 2 n )- in which n has a value of 0 to 4; each of R 8 and R 9 taken independently of the other is hydrogen or alkyl of 1 to 8 carbon atoms, or R 8 and R 9 taken together are tetramethylene, pentamethylene, hexamethylene, or -CH 2 CH 2 XCH 2 CH 2 - in which X is -O-, -S- or -NH-; nR 10 is hydrogen, alkyl of 1 to 8 carbon atoms, or phenyl; and n( b ) the acid addition salts of said compounds which contain a nitrogen atom capable of being protonated.

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