Patent AT-E400300-T1: [Translated] POLYAMINE-METAL CHELATING CONJUGATES
Description
Many metal chelators have polar or charged functional groups, which render them difficult to transport across a cell membrane. Polyamine-metal chelator conjugates of the invention are compounds comprising a first moiety which is a metal chelator and a second moiety which is a polyamine, where the polyamine moiety includes three or more nitrogen atoms which are capable of being positively charged at physiological pH. A spermine-L1 conjugate has been shown to accumulate in L1210 cells several hundred fold more than the unconjugated L1 chelator.
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Access the complete Patent AT-E400300-T1: [Translated] POLYAMINE-METAL CHELATING CONJUGATES on the official website. |
https://pubchem.ncbi.nlm.nih.gov/patent/AT-E400300-T1 |
Tags
- patent
- chemistry
- research
- innovation
- pubchem