Patent AT-E399769-T1: [Translated] SYNTHESIS OF HISTAMINE DIHYDROCHLORIDE
Description
The invention disclosed herein relates to the preparation of pharmaceutical grades of histamine dihydrochloride using a two step non-enzymatic synthetic method. The invention disclosed herein describes the synthesis of histamine dihydrochloride by the non-enzymatic decarboxylation of histidine and the step-wise conversion of the decarboxylated product to the dihydrochloride salt form. The invention disclosed herein considers a final product of histamine dihydrochloride containing less than each of the following: 0.8% L-histidine HCl monohydrate, 0.1% individual chromatographic impurities, and 2% total impurities, to be acceptable for pharmaceutical use.
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Access the complete Patent AT-E399769-T1: [Translated] SYNTHESIS OF HISTAMINE DIHYDROCHLORIDE on the official website. |
https://pubchem.ncbi.nlm.nih.gov/patent/AT-E399769-T1 |
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- chemistry
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- pubchem