UNCERTAINTY OF RBE MODEL IN PROTON RADIOTHERAPY BASED ON α/β RATIO AND LINEAR ENERGY TRANSFER

Description

The dataset includes data from in vitro experiments on 11 cell lines: V79-379A, V79-753B, DLD1, SQ20B, CI-1, C3H10T1/2, SCC25, HCT116, H184B5 F5-1M/10 and HF19 (folder „data”). These data were taken from the survival curves available in the source articles and then a linear-quadratic model was fitted to them , from which the α and β parameters were obtained (04_Distributions, Figure 1). All operations on the experimental data, their reading,  preparation(01_PreaparingData.ipynb) and analysis (02_Fitting_LQmodel.ipynb) were performed in Jupyter Notebooks.   The experimental database has been cleared of outliers based on several conditions(03_Outliers.ipynb). A comparison of biological dose (05_SOBP.ipynb , Figure 2) was set up on a depth-dose and LET profile („data/sobp_10mln”) as being used in radiobiological in vivo mouse experiments (folder „mc_simulation”).   ACKNOWLEDGEMENTS K. Jeleń acknowledges the support of InterDokMed project No. POWR.03.02.00-00-I013/16 

Resources

Name Format Description Link
0 http://data.europa.eu/88u/dataset/oai-zenodo-org-4725840
0 http://data.europa.eu/88u/dataset/oai-zenodo-org-4725840
0 http://data.europa.eu/88u/dataset/oai-zenodo-org-4725840
0 http://data.europa.eu/88u/dataset/oai-zenodo-org-4725840
0 http://data.europa.eu/88u/dataset/oai-zenodo-org-4725840
0 http://data.europa.eu/88u/dataset/oai-zenodo-org-4725840
0 http://data.europa.eu/88u/dataset/oai-zenodo-org-4725840
0 http://data.europa.eu/88u/dataset/oai-zenodo-org-4725840
0 http://data.europa.eu/88u/dataset/oai-zenodo-org-4725840

Tags

  • radiobiology
  • linear-quadratic-model
  • radiotherapy
  • ralative-biological-effectiveness-rbe
  • biological-dose

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