Predicted structures of SLC-protein complexes and controls
Description
Solute carrier (SLC) transporters form a major superfamily which transport a wide range of substrates across cellular and organellar membranes. To study their regulation on protein level and position SLCs in the human interactome, we conducted a large-scale interrogation of the protein-protein interactions (PPIs) of SLCs employing affinity purification combined with mass spectrometry (AP-MS). This study resulted in thousands of novel protein interactions of SLCs. For a subset of SLC protein complexes, we performed structural predictions using AlphaFold (v2.2, v2.3 and v3). The dataset attached contains the structures in PDB/CIF format. The structures were further discussed in the associated manuscript. In addition, an annotation table is provided, which summarizes the scores for each modelled complex.
Resources
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http://data.europa.eu/88u/dataset/oai-zenodo-org-14731200 |
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http://data.europa.eu/88u/dataset/oai-zenodo-org-14731200 |
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http://data.europa.eu/88u/dataset/oai-zenodo-org-14731200 |