Human Lysine Demethylase JMJD1B (KDM3B); A Target Enabling Package
Description
There are 3 members of the Lysine Demethylase JMJD1 (KDM3) family, JMJD1A-C. SGC Oxford has expressed, purified and crystallized the catalytic domains of JMJD1A, JMJD1B and JMJD1C as part of the probe programme. Fragment screening and X-ray crystallography identified a large number of binders, some of which were progressed into a medicinal chemistry programme. Despite significant effort molecules with probe properties were not obtained. Consequently it has been decided to put the information generated into the public domain.
Resources
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http://data.europa.eu/88u/dataset/oai-zenodo-org-1219697 |
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http://data.europa.eu/88u/dataset/oai-zenodo-org-1219697 |
Tags
- neuropsychiatry
- disease
- neurological-genetic-disorders
- structural-genomics
- target-enabling-package
- metabolic-diseases
- structure
- malaria
- kdm3b
- structure-discovery
- drug-target
- protein
- chemical-probe
- orphan-disease
- jmjd1b
- chemical-biology
- cancer
- drug-discovery
- infectious-disease
- oncology
- neuro
- genetics