LacI protein genotype-phenotype landscape data

Description

This data table contains the processed data for the LacI genotype-phenotype landscape, a quantitative measurement of the phenotype for approximately 60,000 variants of the E. coli LacI protein. The table includes, for example, the DNA barcode sequencing counts and the estimated fitness for each variant across 24 different chemical environments. It also includes the estimated dose-response curves for each variant under induction with IPTG.

Resources

Name Format Description Link
5 https://data.nist.gov/od/ds/ark:/88434/mds2-2259/Example%20code_Open%20LacI%20Data%20Table.ipynb
8 LacI%20landscape%20data%20columns%20description.csv https://data.nist.gov/od/ds/ark:/88434/mds2-2259/LacI%20landscape%20data%20columns%20description.csv
20 LacI%20landscape%20data.hdf https://data.nist.gov/od/ds/ark:/88434/mds2-2259/LacI%20landscape%20data.hdf
47 https://data.nist.gov/od/ds/ark:/88434/mds2-2259/LacI%20landscape%20data%20columns%20description.csv.sha256
0 https://doi.org/10.18434/M32259
47 https://data.nist.gov/od/ds/ark:/88434/mds2-2259/Example%20code_Open%20LacI%20Data%20Table.ipynb.sha256
47 https://data.nist.gov/od/ds/ark:/88434/mds2-2259/LacI%20landscape%20data.hdf.sha256

Tags

  • allostery
  • e-coli
  • dna-barcode-sequencing
  • genotype-phenotype-relationships
  • engineering-biology
  • lac-repressor
  • fitness-landscape

Topics

Categories