In Vivo PK Library for IVIVE Evaluation

Description

We report on new, in vivo TK experiments in rats for 26 chemicals more commonly associated with non-therapeutic and/or unintentional exposure. These chemicals, and an additional 19 chemicals from previously published in vivo rat studies, were systematically analyzed to estimate relevant TK parameters (e.g., volume of distribution, elimination rate). Our analysis created a library of TK parameters for 38 chemicals for which rat-specific in vitro HTTK data were also available. This dataset is associated with the following publication: Wambaugh, J., M. Hughes, C. Ring, D. MacMillan, J. Ford, T. Fennell, S. Black, R. Snyder, N. Sipes, B. Wetmore, J. Westerhout, W. Setzer, R. Pearce, J. Simmons, and R. Thomas. Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 163(1): 152-169, (2018).

Resources

Name Format Description Link
53 TableS9-InVivoData-2017-08-10.xlsx https://pasteur.epa.gov/uploads/10.23719/1390274/TableS9-InVivoData-2017-08-10.xlsx
33 FiguresS1-1compartment-Fittedgeometricmean-2017-08-29.pdf https://pasteur.epa.gov/uploads/10.23719/1390274/FiguresS1-1compartment-Fittedgeometricmean-2017-08-29.pdf
33 FiguresS2-2compartment-Fittedgeometricmean-2017-08-29.pdf https://pasteur.epa.gov/uploads/10.23719/1390274/FiguresS2-2compartment-Fittedgeometricmean-2017-08-29.pdf
10 SupplementalTables1-8.docx https://pasteur.epa.gov/uploads/10.23719/1390274/SupplementalTables1-8.docx
53 TableS10-PropertiesandEstimates-2017-08-30.xlsx https://pasteur.epa.gov/uploads/10.23719/1390274/TableS10-PropertiesandEstimates-2017-08-30.xlsx
53 TableS11-TKSummaryStats-2017-08-30.xlsx https://pasteur.epa.gov/uploads/10.23719/1390274/TableS11-TKSummaryStats-2017-08-30.xlsx

Tags

  • analytical-chemistry
  • toxicokinetics
  • exposure
  • expocast
  • in-vitro-to-in-vivo-extrapolation-ivive

Topics

Categories