Description
Data sets include
1. Excel file with Hershberger assay protocols and data and summaries of in vivo antiandrogen studies
2. Figures of in vitro AR assay results from contract work and in house studies
3. Excel file with in house in vitro AR antagonism data.
This dataset is associated with the following publication:
Gray, L., J. Furr, C. Lambright, N. Evans, P. Hartig, M. Cardon, V. Wilson, A. Hotchkiss, and J. Conley. Quantification of uncertainties in extrapolating from in vitro androgen receptor (AR) antagonism to in vivo Hershberger Assay endpoints and adverse reproductive development in male rats. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 176(2): 297-311, (2020).
Resources
| Name | Format | Description | Link |
|---|---|---|---|
| AR phase 1 2 and 3 ED50 and binding ceetox figures.pdf | AR%20%20phase%201%202%20%20and%203%20ED50%20and%20binding%20ceetox%20figures.pdf | Open resource | |
| DR VS WILSON 2010 SOT POSTER WITH IN VITRO ANDROGEN RECEPTOR DATA.pdf | DR%20VS%20WILSON%202010%20SOT%20POSTER%20WITH%20IN%20VITRO%20ANDROGEN%20RECEPTOR%20DATA.pdf | Open resource | |
| mda kb2 and CV-1 transduction Antagonists and antagonists data from RTB Team FOR SCIENCE HUB.xlsx | XLS | mda%20kb2%20and%20CV-1%20transduction%20%20Antagonists%20and%20antagonists%20data%20from%20RTB%20Team%20FOR%20SCIENCE%20HUB.xlsx | Open resource |
| OUR HERSHBERGER STUDIES FOR SCIENCE HUB.xlsx | XLS | OUR%20HERSHBERGER%20STUDIES%20FOR%20SCIENCE%20HUB.xlsx | Open resource |