IN VITRO AND IN VIVO ANDROGEN RECEPTOR DATA SET FROM TOX SCI PAPER GRAY ET AL 2020

Description

Data sets include 1. Excel file with Hershberger assay protocols and data and summaries of in vivo antiandrogen studies 2. Figures of in vitro AR assay results from contract work and in house studies 3. Excel file with in house in vitro AR antagonism data. This dataset is associated with the following publication: Gray, L., J. Furr, C. Lambright, N. Evans, P. Hartig, M. Cardon, V. Wilson, A. Hotchkiss, and J. Conley. Quantification of uncertainties in extrapolating from in vitro androgen receptor (AR) antagonism to in vivo Hershberger Assay endpoints and adverse reproductive development in male rats. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 176(2): 297-311, (2020).

Resources

Name Format Description Link
33 DR%20VS%20WILSON%202010%20SOT%20POSTER%20WITH%20IN%20VITRO%20ANDROGEN%20RECEPTOR%20DATA.pdf https://pasteur.epa.gov/uploads/10.23719/1520150/DR%20VS%20WILSON%202010%20SOT%20POSTER%20WITH%20IN%20VITRO%20ANDROGEN%20RECEPTOR%20DATA.pdf
53 OUR%20HERSHBERGER%20STUDIES%20FOR%20SCIENCE%20HUB.xlsx https://pasteur.epa.gov/uploads/10.23719/1520150/OUR%20HERSHBERGER%20STUDIES%20FOR%20SCIENCE%20HUB.xlsx
53 mda%20kb2%20and%20CV-1%20transduction%20%20Antagonists%20and%20antagonists%20data%20from%20RTB%20Team%20FOR%20SCIENCE%20HUB.xlsx https://pasteur.epa.gov/uploads/10.23719/1520150/mda%20kb2%20and%20CV-1%20transduction%20%20Antagonists%20and%20antagonists%20data%20from%20RTB%20Team%20FOR%20SCIENCE%20HUB.xlsx
33 AR%20%20phase%201%202%20%20and%203%20ED50%20and%20binding%20ceetox%20figures.pdf https://pasteur.epa.gov/uploads/10.23719/1520150/AR%20%20phase%201%202%20%20and%203%20ED50%20and%20binding%20ceetox%20figures.pdf

Tags

  • hershberger-assay
  • in-vitro-in-vivo-extrapolation
  • in-utero-effects-on-male-reproductive-development
  • antiandrogens
  • quantitative-aop-for-androgen-receptor-antagonistsr
  • androgen-receptor

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