Impact of Scaling Factor Variability on Risk Relevant Outcomes in Children
Description
This dataset contains physiologically-based (PBPK) model code and parameter settings supporting the manuscript titled "THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC OUTCOMES IN CHILDREN: A CASE STUDY USING BROMODICHLOROMETHANE (BDCM)".
This dataset is associated with the following publication:
Kenyon, E., J. Lipscomb, R. Pegram, B. George, and R. Hines. THE IMPACT OF SCALING FACTOR VARIABILITY ON RISK-RELEVANT PHARMACOKINETIC OUTCOMES IN CHILDREN: A CASE STUDY USING BROMODICHLOROMETHANE (BDCM). TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 167(2): 347-359, (2019).
Resources
| Name |
Format |
Description |
Link |
|
33 |
ModelFile_BDCM_peds.pdf |
https://pasteur.epa.gov/uploads/10.23719/1407661/ModelFile_BDCM_peds.pdf |
|
33 |
ModelParameters_PedsScalingVariability.pdf |
https://pasteur.epa.gov/uploads/10.23719/1407661/ModelParameters_PedsScalingVariability.pdf |
Tags
- pediatric
- trihalomethanes
- children
- variability
- global-sensitivity-analysis
- scaling-factors
- age-related-susceptibility
- in-vitro-to-in-vivo-extrapolation-ivive
- bromodichloromethane