Illumina NGS RNA-seq and RRBS Sequencing on Spaceflight Mouse Retina

This study was under the umbrella of the NASA Rodent Research-1 project consortium. In this project, 16-week-old female C57 BL/6J mice were sent to International Space Station (ISS) in NASA's animal enclosure modules (AEM) and were kept inside ISS middeck for 37 days. We used transcrptomic and methylomic approaches to investigated the spaceflight-associated neuro-ocular syndrome (SANS) using retinas from those spaceflight mice.