Data for: Randomized trial of neoadjuvant palbociclib and endocrine therapy versus chemotherapy in ER+/HER2- breast cancer (PREDIX LumB): Primary analysis and development of the CDKPredX metagene predictor
Description
The dataset contains whole-exome sequencing (WES) and RNA sequencing (RNA-Seq) FASTQ files derived from tumor tissue samples collected in the PREDIX Lum B clinical trial (prospective randomized phase II, ClinicalTrials.gov ID: NCT02603679) conducted at three hospitals in Sweden. In total, the dataset includes 166 WES samples and 163 RNA-Seq samples. For WES, matched normal blood samples are also included. Metadata file containing patient anonymized ID, treatment arm, gender, and the corresponding WES and RNA-seq sample anonymized IDs.
Files are organized by sequencing type (WES and RNA-Seq), plus a metadata table listing all variables: trial ID, gender, treatment arm, and associated file paths.
No specialized software is required to open the FASTQ files or metadata. Downstream analysis requires related bioinformatics tools.
The dataset consists of:
- 4,974 FASTQ files, compressed as GNU zip files
- 3 CSV files
- 1 readme file in TXT format
The total size of the dataset is approximately 7.6 TB
Resources
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http://data.europa.eu/88u/dataset/https-doi-org-10-48723-j14a-6r76 |