Activating mutations remodeled the chromatin accessibility landscape to drive distinct regulatory networks in KMT2A-rearranged acute leukemia associated with immune evasion

This dataset includes ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) of five infants with acute lymphoblastic leukemia. All patients had an underlying rearrangement of the KMT2A genes, either KMT2A::MLLT1 (n=1), KMT2A::AFF1 (n=3), or KMT2A::MLLT10 (n=1). Three patients also had activating mutations of NRAS G13D and/or KRAS G12D. The median age of the cohort was 2 months 7 days. Diagnostic sample from bone marrow underwent the ATAC-seq library preparation and sequenced on the NextSeq 500 platform (Illumina, San Diego, CA, USA).