Selection of dicamba synthesis method for technological application

The synthesis and herbicidal properties of 3,6-dichloro-2-methoxybenzoic acid - dicamba have been known since the early 1960s.

Since then, a continuous development of dicamba synthesis methods has been observed, which is stimulated by, among others, advances in research on the methods of introducing functional groups into the benzene ring as well as the influence of the groups present in the ring on the position occupied by the new substituent.

3,6-Dichloro-2-methoxybenzoic acid is a tetrasubstituted benzene derivative with no symmetry elements, in which the functional groups occupy the 1,2,3,4 positions.

This has its implications in the synthesis of this type of structures, which include, among others, on problems related to the regioselectivity of the reaction (influence of steric and electronic factors) as well as the reactivity of the reagents.

Research material content:

I. Literature research on dicamba synthesis methods

II. Laboratory research on the preparation of dicamba by the method: bromination / hydroxymethylation / debromination / methylation / oxidation

III. Laboratory studies on the preparation of dicamba by the method of: acetylation / Fries rearrangement / O - methylation / haloform reaction

IV. Laboratory research on the preparation of dicamba by the Kolbe - Schmitt carboxylation / O - methylation