Description
To determine whether IL-4 is therapeutic in treating established
experimental arthritis, a recombinant adenovirus carrying the gene that encodes
murine IL-4 (Ad-mIL-4) was used for periarticular injection into the ankle
joints into mice with established collagen-induced arthritis (CIA).
Periarticular injection of Ad-mIL-4 resulted in a reduction in the severity of
arthritis and joint swelling compared with saline- and adenoviral control
groups. Local expression of IL-4 also reduced macroscopic signs of joint
inflammation and bone erosion. Moreover, injection of Ad-mIL-4 into the hind
ankle joints resulted in a decrease in disease severity in the untreated front
paws. Systemic delivery of murine IL-4 by intravenous injection of Ad-mIL-4
resulted in a significant reduction in the severity of early-stage
arthritis.
Resources
| Name | Format | Description | Link |
|---|---|---|---|
| Official Government Data Source | HTML | Visit the original government dataset for complete information, documentation, and data access. | Open resource |