formalin effects data

Description

RNA sequencing data from paired: (1) fresh-frozen, (2) direct-fixed in formalin for 18 hours, (3) frozen then formalin-fixed, or (4) frozen then ethanol-fixed and paraffin-embedded (n=6/group/condition) tissue samples from the livers of mice exposed to 600 ppm phenobarbital vs. vehicle control for 7 days in drinking water. RNA sequencing data from paired fresh frozen and 18 hr. formalin-fixed paraffin-embedded liver tissue from mice administered 1500, 3000, and 6000 ppm DEHP or vehicle control for 7 days by dietary ingestion; or RNA sequencing data from paired fresh frozen, 18 hr. formalin fixed paraffin embedded, or 3 wk. formalin fixed paraffin embedded liver tissue from mice administered 8 mg/kg/d Furan or vehicle control for 3 weeks by gavage. This dataset is associated with the following publication: Wehmas, L., S. Hester, and C.E. Wood. Direct Formalin Fixation Induces Widespread Transcriptomic Effects in Archival Tissue Samples. Scientific Reports. Nature Publishing Group, London, UK, 10: 14497, (2020).

Resources

Name Format Description Link
53 Formalin_effect_MS_Master_Table_2_20200728.xlsx https://pasteur.epa.gov/uploads/10.23719/1518503/Formalin_effect_MS_Master_Table_2_20200728.xlsx
53 Formalin_effect_MS_Master_Table_20200728_complete.xlsx https://pasteur.epa.gov/uploads/10.23719/1518503/Formalin_effect_MS_Master_Table_20200728_complete.xlsx
53 Formalin_effect_MS_Master_Table_3_20200728.xlsx https://pasteur.epa.gov/uploads/10.23719/1518503/Formalin_effect_MS_Master_Table_3_20200728.xlsx
53 Formalin_effect_MS_Master_Table_4_20200728.xlsx https://pasteur.epa.gov/uploads/10.23719/1518503/Formalin_effect_MS_Master_Table_4_20200728.xlsx
10 Formalin_effects_manuscript_supplementary_table_legends.docx https://pasteur.epa.gov/uploads/10.23719/1518503/Formalin_effects_manuscript_supplementary_table_legends.docx

Tags

  • dehp
  • molecular-pathway-analysis
  • phenobarbital
  • furan
  • formalin-fixed-paraffin-embedded-samples
  • rna-sequencing
  • gene-expression-profiles
  • mode-of-action-moa

Topics

Categories