Expression profiling of murine lung 70 days following exposure to fractionated or acute dose of 1.0 Gy 56Fe- particle irradiation
Description
Irradiation of the K-rasLA1 mouse model with a fractionated dose of 1.0Gy 56Fe- particles increases the incidence of invasive carcinoma compared to unirradiated controls or those irradiated with an acute dose. Microarray profiling was perfromed on whole lungs from K-rasLA1 mice in order to determine global expression changes in the lung following radiation exposure. RNA was extracted from K-rasLA1 lungs from unirradiated control animals or those irradiated with a fractionated or acute dose of 1.0Gy 56Fe- particles 70 days post-irradiation when lungs are still histologically indistiguishable and only contain benign lesions. 129S2 K-rasLA1 mice were either irradiated with an acute (1.0Gy x1; n = 15) or fractionated (0.2Gy x5; n=13) dose of 1.0Gy 56Fe- particles or left unirradiated (n=13). Animals were euthanized 70 days post-irradiation and RNA was extracted from the whole left lung of each animal.
Resources
| Name |
Format |
Description |
Link |
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21 |
GeneLab Study Page |
https://genelab-data.ndc.nasa.gov/genelab/accession/GLDS-148 |
Tags
- p-gse42233-7
- p-gse42233-6
- ionizing-radiation
- sample-treatment-protocol
- p-gse42233-4
- sex
- fractionated-dose
- array-scanning-protocol
- hybridization-protocol
- p-gse42233-2
- p-gse42233-1
- growth-protocol
- p-gse42233-5
- nucleic-acid-extraction-protocol
- labelling-protocol
- p-gse42233-3
- normalization-data-transformation-protocol