Evaluation of the potential effects of three chemicals on the hypothalamic-pituitary-thyroid (HPT) and hypothalamic-pituitary-gonadal (HPG) axes using the Larval Amphibian Growth and Development Assay (LAGDA)

Description

Three chemicals, 2-ethylhexyl 4-hydroxybenzoate (2-EHHB), 5-chloro-2-(2,4-dichlorophenoxy) phenol (triclosan), and 4-nonylphenol, branched (4-NP) were evaluated using the Larval Amphibian Growth and Development Assay (LAGDA) to investigate endocrine-mediated effects. A delay in development to NF stage 62 was observed for the three chemicals, however, histopathological evaluation revealed that the effects were likely not thyroid related. 4-NP caused increased stage scores in male and female gonadal duct development. Citation information for this dataset can be found in Data.gov's References section.

Resources

Name Format Description Link
10 Larval%20Amphibian%20Growth%20and%20Development%20Assay%20%28LAGDA%29%20of%20Triclosan.docx https://pasteur.epa.gov/uploads/10.23719/1532344/Larval%20Amphibian%20Growth%20and%20Development%20Assay%20%28LAGDA%29%20of%20Triclosan.docx
10 Larval%20Amphibian%20Growth%20and%20Development%20Assay%20%28LAGDA%29%20of%204-nonylphenol.docx https://pasteur.epa.gov/uploads/10.23719/1532344/Larval%20Amphibian%20Growth%20and%20Development%20Assay%20%28LAGDA%29%20of%204-nonylphenol.docx
10 Larval%20Amphibian%20Growth%20and%20Development%20Assay%20%28LAGDA%29%20of%202-Ethylhexyl%204-Hydroxybenzoate%20.docx https://pasteur.epa.gov/uploads/10.23719/1532344/Larval%20Amphibian%20Growth%20and%20Development%20Assay%20%28LAGDA%29%20of%202-Ethylhexyl%204-Hydroxybenzoate%20.docx

Tags

  • 2-ethylhexyl-4-hydroxybenzoate
  • endocrine-disruption
  • lagda
  • triclosan
  • amphibian
  • xenopus
  • 4-nonylphenol

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