Replication Data for: A multiscale model for in silico trials of ascending thoracic aortic aneurysm treatment in Marfan syndrome
Description
This dataset contains a MATLAB implementation of a computational model to predict multiscale growth and remodeling of ascending thoracic aortic aneurysms in Marfan syndrome. The model contains a tissue-scale mechanical description of the aneurysm and a cell-scale signaling and gene regulatory network for the aneurysm smooth muscle cells. The model was calibrated and validated using data from animal experiments. The model is used to perform an in silico trial to predict changes in aneurysm rupture risk upon perturbation of the nodes in the cell-scale model.
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Tags
- computer-simulation
- marfan-syndrome
- aortic-aneurysm,-thoracic