Datasets associated with "Mining of Consumer Product and Purchasing Data to Identify Potential Chemical Co-exposures"

Description

Background: Chemicals in consumer products are a major contributor to human chemical co-exposures. Consumers purchase and use a wide variety of products containing potentially thousands of chemicals. There is a need to identify potential real-world chemical co-exposures in order to prioritize in vitro toxicity screening. However, due to the vast number of potential chemical combinations, this has been a major challenge. Objectives: We aim to develop and implement a data-driven procedure for identifying prevalent chemical combinations to which humans are exposed through purchase and use of consumer products. Methods: We applied frequent itemset mining on an integrated dataset linking consumer product chemical ingredient data with product purchasing data from sixty thousand households to identify chemical combinations resulting from co-use of consumer products. Results: We identified co-occurrence patterns of chemicals over all households as well as those specific to demographic groups based on race/ethnicity, income, education, and family composition. We also identified chemicals with the highest potential for aggregate exposure by identifying chemicals occurring in multiple products used by the same household. Lastly, a case study of chemicals active in estrogen and androgen receptor in silico models revealed priority chemical combinations co-targeting receptors involved in important biological signaling pathways. Discussion: Integration and comprehensive analysis of household purchasing data and product-chemical information provided a means to assess human near-field exposure and inform selection of chemical combinations for high-throughput screening in in vitro assays. This dataset is associated with the following publication: Stanfield, Z., C. Addington, K. Dionisio, D. Lyons, R. Tornero-Velez, K. Phillips, T. Buckley, and K. Isaacs. Mining of consumer product and purchasing data to identify potential chemical co-exposures.. ENVIRONMENTAL HEALTH PERSPECTIVES. National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC, USA, 129(6): N/A, (2021).

Resources

Name Format Description Link
53 ScienceHub_FIMofNielsenAndCPCat_2020-06-03.xlsx https://pasteur.epa.gov/uploads/10.23719/1519316/ScienceHub_FIMofNielsenAndCPCat_2020-06-03.xlsx

Tags

  • frequent-itemset-mining-fim
  • chemical-exposure
  • aggregate-exposure
  • expocast
  • consumer-products

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