Data for: Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays

Description

This dataset contains the raw data, Area under the curve measurements and EC50 values for effects of 146 compounds (136 unique plus 10 biological replicates) on parameters of network development measured in vitro. There are 17 parameters plus 2 measures of viability. In addition, the data for the ranking of potency and selectivity are provided, as well as data for the comparisons to other ToxCast assays and in vitro to in vivo extrapolations. This dataset is associated with the following publication: Shafer, T., J. Brown, B. Lynch, S. Davila-Montero, K. Wallace, and K. Paul-Friedman. Evaluation of Chemical Effects on Network Formation in Cortical Neurons Grown on Microelectrode Arrays. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 169(2): 436-455, (2019).

Resources

Name Format Description Link
53 MEA_and_ToxCast_and%20AEDs_for_TC_NTP_25Oct2018.xlsx https://pasteur.epa.gov/uploads/10.23719/1503191/MEA_and_ToxCast_and%20AEDs_for_TC_NTP_25Oct2018.xlsx
53 Excel%20scatter%20plot%20potency%20vs%20viability_Nov_26_2018.xlsx https://pasteur.epa.gov/uploads/10.23719/1503191/Excel%20scatter%20plot%20potency%20vs%20viability_Nov_26_2018.xlsx
53 Excel_selectivity_Oct%2026_2018_alt.xlsx https://pasteur.epa.gov/uploads/10.23719/1503191/Excel_selectivity_Oct%2026_2018_alt.xlsx
57 NTP_TC_Analysis.zip https://pasteur.epa.gov/uploads/10.23719/1503191/NTP_TC_Analysis.zip

Tags

  • developmental-neurotoxicity
  • microelectrode-array
  • chemical-screening
  • in-vitro-assay

Topics

Categories