Conversion of environmental estrone to estradiol by male fathead minnows
Description
This data set describes experiments that were conducted to investigate whether exposure of male fathead minnows to environmentally-relevant estrone concentrations would result in elevated plasma 17β-estradiol concentrations in the fish. Secondly, we sought to establish whether observed elevations in plasma 17β-estradiol occurred as a result of the conversion of external estrone by the fish using an approach involving exposure of the fish to 13C-labeled estrone. Endpoints reported in the dataset include plasma 17β-estradiol and estrone concentrations, plasma vitellogenin concentrations, hepatic vitellogenin mRNA, 13C-labeled plasma 17β-estradiol and estrone concentrations, and testicular and/or hepatic expression of aromatase and several hydroxysteroid dehydrogenases involved in estrone metabolism.
This dataset is associated with the following publication:
Ankley, G., D. Feifarek, B. Blackwell, J. Cavallin, K. Jensen, M. Kahl, S. Poole, E. Randolph, T. Saari, and D. Villeneuve. Reevaluating the significance of estrone as an environmental estrogen (article). ENVIRONMENTAL SCIENCE & TECHNOLOGY. American Chemical Society, Washington, DC, USA, 51: 4705-4713, (2017).
Resources
| Name |
Format |
Description |
Link |
|
53 |
AnkleyGerald_A-cjt8_Dataset%20Estrone.xlsx |
https://pasteur.epa.gov/uploads/10.23719/1369435/AnkleyGerald_A-cjt8_Dataset%20Estrone.xlsx |
Tags
- screening-and-prioritization
- endocrine-disruption
- estradiol
- environmental-estrogens
- ecotoxicology
- estrone
- adverse-outcome-pathway
- aquatic-ecosystems