Computational Estimates of Aggregate Exposure to PFOA/PFOS from 2011-2017 Using a Basic Intake and Pharmacokinetic Model

Description

General aggregate PFOS and PFOA exposure estimates are based on reported summary statistics from concentration studies by media, i.e. into indoor air, outdoor air, food, water, dust and soil, and published contact rates. These values were entered into a first-order PK model to estimate PFOS and PFOA blood serum concentrations. which were then compared measured concentrations reported by the 2013-2014 National Health and Nutrition Examination Survey (NHANES) measured concentrations. These methods are an expansion of the process taken by two previous studies, which predicted body burden from aggregate route intakes for PFOA and for PFOS, respectively. This dataset is associated with the following publication: East, A., P. Egeghy, E. Hubal, R. Slover, and D. Vallero. Computational estimates of daily aggregate exposure to PFOA/PFOS from 2011 to 2017 using a basic intake model. Journal of Exposure Science and Environmental Epidemiology. Nature Publishing Group, London, UK, 33: 56-68, (2023).

Resources

Name Format Description Link
53 Input%2010052020%20pfos_pfoa%20dav.xlsx https://pasteur.epa.gov/uploads/10.23719/1520464/Input%2010052020%20pfos_pfoa%20dav.xlsx
53 PFOA%20PFOS%20Intake%20Results%2020201005%20dav.xlsx https://pasteur.epa.gov/uploads/10.23719/1520464/PFOA%20PFOS%20Intake%20Results%2020201005%20dav.xlsx

Tags

  • per-and-polyfluoroalkyl-substances-pfas
  • perfluorooctane-sulfonate-pfos
  • perfluoroctanoic-acid-pfoa
  • aggregate-exposure-estimation
  • data-curation
  • pharmacokinetic-pk-model

Topics

Categories