Description

This study evaluated the effects of bisphenol A exposure on the freshwater snail Planorbella pilsbryi using metabolomics to identify perturbations in metabolites and lipids at the molecular level. Snails were exposed to bisphenol A in a chronic 28-day test and the tissue was collected for analysis at the end of the exposure. The analytical approach involved a liquid-liquid extraction of the tissues, the detection and annotation of metabolites and lipids using liquid chromatography tandem mass spectrometry, and overrepresentation analysis to identify those biological pathways affected by the exposure. A manuscript describing methods, processes, and conclusions has been submitted for peer-review will be published in the near future. Supplemental Information The Chemicals Management Plan (CMP) is a Government of Canada initiative aimed at reducing the risks posed by chemicals to Canadians and their environment. A key element of the Chemicals Management Plan is the monitoring and surveillance of levels of harmful chemicals in Canadians and their environment. Monitoring and surveillance are essential to identify and track exposure to hazards in the environment and associated health implications. Monitoring and surveillance programs provide the basis for making sound and effective public health and environmental health policies and interventions, as well as measuring the efficacy of control measures. In support of the Chemicals Management Plan, monitoring and surveillance initiatives were established to support Health Canada and Environment and Climate Change Canada scientists, in collaboration with external partners and researchers, to advance our knowledge. This initiative has allowed the Government of Canada to increase its commitment to a number of existing monitoring initiatives, as well as to support new efforts. For more information on the Chemicals Management Plan, please visit https://www.canada.ca/en/health-canada/services/chemical-substances/chemicals-management-plan.html

Resources

Name	Format	Description	Link
CMP_BPA_MetabolomicsMetabolomique_OverRepresentationSurrePresentation_Ppilsbryi_EN-FR	CSV		https://data-donnees.az.ec.gc.ca/api/file?path=%2Fsubstances%2Fassess%2Ftoxicity-and-bioconcentration-of-bisphenol-a-and-bisphenol-alternatives-on-the-freshwater-gastropod-planorbella-pilsbryi%2Fnon-targeted-metabolomics-reveals-multi-pathway-disruption-BPA-exposure-freshwater-snail-planorbella-pilsbryi%2FCMP_BPA_MetabolomicsMetabolomique_OverRepresentationSurrePresentation_Ppilsbryi_EN-FR.csv
CMP_BPA_MetabolomicsMetabolomique_Ppilsbryi_EN-FR	CSV		https://data-donnees.az.ec.gc.ca/api/file?path=%2Fsubstances%2Fassess%2Ftoxicity-and-bioconcentration-of-bisphenol-a-and-bisphenol-alternatives-on-the-freshwater-gastropod-planorbella-pilsbryi%2Fnon-targeted-metabolomics-reveals-multi-pathway-disruption-BPA-exposure-freshwater-snail-planorbella-pilsbryi%2FCMP_BPA_MetabolomicsMetabolomique_Ppilsbryi_EN-FR.csv
View ECCC Data Mart (English)	HTML		https://data-donnees.az.ec.gc.ca/data/substances/assess/toxicity-and-bioconcentration-of-bisphenol-a-and-bisphenol-alternatives-on-the-freshwater-gastropod-planorbella-pilsbryi/non-targeted-metabolomics-reveals-multi-pathway-disruption-BPA-exposure-freshwater-snail-planorbella-pilsbryi?lang=en
View ECCC Data Mart (French)	HTML		https://data-donnees.az.ec.gc.ca/data/substances/assess/toxicity-and-bioconcentration-of-bisphenol-a-and-bisphenol-alternatives-on-the-freshwater-gastropod-planorbella-pilsbryi/non-targeted-metabolomics-reveals-multi-pathway-disruption-BPA-exposure-freshwater-snail-planorbella-pilsbryi?lang=fr

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