Bioactivity of the ubiquitous tire preservative 6PPD and degradant, 6PPD-quinone in fish and mammalian-based assays
Description
The data set contains data for the following assays performed using 6PPD-quinone and/or 6PPD. 1) Larval fathead minnow transcriptomics; 2) larval fathead minnow EcoToxChips [6PPD-quinone only]; 3) zebrafish developmental and behavioral toxicity; 4) cell painting and cytotoxicity in the rainbow trout gill cell line, RTgill-W1; 5) acute and developmental neurotoxicity (DNT) assays in mammalian cells; 6) Attagene FACTORIAL assays with human hepatoma cells [6PPD-quinone only]; and 7) analytical assessment of 6PPD and 6PPD-quinone stability in RTgill-W1 and DNT assay media.
This dataset is associated with the following publication:
Jankowski, M., A. Carpenter, J. Harrill, D. Harris, B. Hill, R. Labiosa, S. Makarov, D. Martinovic-Weigelt, J. Nyffeler, S. Padilla, T. Shafer, M. Smeltz, and D. Villeneuve. Bioactivity of the ubiquitous tire preservative 6PPD and degradant, 6PPD-quinone in fish- and mammalian-based assays. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 204(2): 198-217, (2025).
Resources
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https://clowder.edap-cluster.com/datasets/677ab279e4b0a7c65d3994d3 |
Tags
- chemicals
- bioactivity
- computational-toxicology
- ambient-water
- new-approach-methods-alternatives-to-animal-testing