Benchmark Dose Modeling Approaches for Volatile Organic Chemicals using a Novel Air-Liquid Interface In Vitro Exposure System

Description

Whole transcriptomics dose response data is collected and storedthrough public facing Gene Expression Omnibus database. Raw collected viability/cytotoxicity data for each chemical are collected and presented on separate spreadsheets. Portions of this dataset are inaccessible because: The transcriptomics full data file is too large to be uploaded alone onto ScienceHub, impeding ease of access. They can be accessed through the following means: Raw and processed transcriptomics data is available through Gene Expression Omnibus (GEO, https://www.ncbi.nlm.nih.gov/geo/) under accession GSE199794. Format: The full transcriptomics data set for all chemical conditions tested. This dataset is associated with the following publication: Speen, A., J. Murray, T. Krantz, D. Davies, P. Evansky, J. Harrill, L. Everett, J. Bundy, L. Dailey, W. Zander, E. Carlsten, M. Monsees, J. Hill, J. Zavala, and M. Higuchi. Benchmark Dose Modeling Approaches for Volatile Organic Chemicals using a Novel Air-Liquid Interface In Vitro Exposure System. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 188(1): 88-107, (2022).

Resources

Name Format Description Link
53 1-Bromopropane%20Sample%20ID%20and%20Exposure%20Conditions.xlsx https://pasteur.epa.gov/uploads/10.23719/1524251/1-Bromopropane%20Sample%20ID%20and%20Exposure%20Conditions.xlsx
53 1%2C3-butadiene%20Sample%20ID%20and%20exposure%20conditions.xlsx https://pasteur.epa.gov/uploads/10.23719/1524251/1%2C3-butadiene%20Sample%20ID%20and%20exposure%20conditions.xlsx
53 Acetaldehyde%20Sample%20ID%20and%20Exposure%20Conditions.xlsx https://pasteur.epa.gov/uploads/10.23719/1524251/Acetaldehyde%20Sample%20ID%20and%20Exposure%20Conditions.xlsx
53 Acrolein%20Sample%20ID%20and%20Exposure%20Conditions.xlsx https://pasteur.epa.gov/uploads/10.23719/1524251/Acrolein%20Sample%20ID%20and%20Exposure%20Conditions.xlsx
53 Formaldehyde%20Sample%20ID%20and%20Exposure%20Conditions.xlsx https://pasteur.epa.gov/uploads/10.23719/1524251/Formaldehyde%20Sample%20ID%20and%20Exposure%20Conditions.xlsx
53 Carbon%20Tetrachloride%20Sample%20ID%20and%20Exposure%20Conditions.xlsx https://pasteur.epa.gov/uploads/10.23719/1524251/Carbon%20Tetrachloride%20Sample%20ID%20and%20Exposure%20Conditions.xlsx
53 Trichloroethylene%20Sample%20ID%20and%20Exposure%20Conditions.xlsx https://pasteur.epa.gov/uploads/10.23719/1524251/Trichloroethylene%20Sample%20ID%20and%20Exposure%20Conditions.xlsx
53 Dichloromethane%20Sample%20ID%20and%20Exposure%20Conditions1.xlsx https://pasteur.epa.gov/uploads/10.23719/1524251/Dichloromethane%20Sample%20ID%20and%20Exposure%20Conditions1.xlsx

Tags

  • volatile-organic-compound-voc
  • airway-epithelial-cells
  • transcriptomics

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