Topas cell model with nanoparticles
Description
These files contain cell models for TOPAS/Geant4 and the inclusion of nano particles in particle scattering simulations. A simple spherical cell with nanoparticles can be generated in a fast way. The user has the option to include the following organelles: nucleus, mitochondria, cell membrane. Additionally, nanoparticles can be included in the cytosol and at the surface of the nucleus and/or the mitochondria.
The C++ classes in this repository extend the functionality of the TOPAS (http://www.topasmc.org/) Monte-Carlo program, which is itself a wrapper of the Geant4 MCS Toolkit (http://geant4.org). The sourcecode together with examples and scorers are provided.
If you use this extension please cite the following literature:
Hahn, M.B., Zutta Villate, J.M., “Combined cell and nanoparticle models for TOPAS to study radiation dose enhancement in cell organelles.” Sci Rep 11, 6721 (2021).
https://doi.org/10.1038/s41598-021-85964-2»
Resources
| Name |
Format |
Description |
Link |
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57 |
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https://doi.org/10.26272/opus4-51150 |
Tags
- mcs
- aunp
- radiation-therapy
- cell
- dosimetry
- mitochondria
- nucleus
- gold
- targeted-nanoparticle
- microdosimetry
- particle-scattering
- monte-carlo-simulation
- cancer-therapy
- nanoparticles
- nanoparticle
- topas
- topas-nbio
- geant4
- simulation