ATP BINDING CASSETTE SUB-FAMILY MEMBER 2 (ABCG2) AND XENOBIOTIC EXPOSURE DURING EARLY MOUSE EMBRYONIC STEM CELL DIFFERENTIATION

Description

ATP binding cassette sub-family member 2 (ABCG2) is a well-defined efflux transporter found in various tissues. The role of ABCG2 during early embryonic development, however, is not established. Previous work suggested an association exists between xenobiotics that regulate Abcg2 transcription and differentiation of mouse embryonic stem cells (mESC), a relationship potentially related to redox homeostasis. ABCG2 was found to serve protective role in mESC as a xenobiotic transporter. The role of ABCG2 in regulating redox status, however, was unclear. The hypothesis that ABCG2 plays a fundamental role during mESC differentiation or that regulation of the receptor by xenobiotics may be associated with altered mESC differentiation could not be supported. This dataset is associated with the following publication: Rosen, M., S. Jeffay, H. Nichols, M. Hoopes, and S. Hunter. ATP Binding Cassette Sub-Family Member 2 (ABCG2) And Xenobiotic Exposure During Early Mouse Embryonic Stem Cell Differentiation. Birth Defects Research. John Wiley & Sons, Inc., Hoboken, NJ, USA, 110(1): 35-47, (2017).

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Tags

  • abcg2
  • xenobiotics
  • redox-stress
  • mouse-embryonic-stem-cell
  • toxcast
  • differentiation

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