Assessment of the Bioaccessibility of Micronized Copper Wood on Simulated Stomach Fluid
Description
The widespread use of copper-treated lumber has increased the potential for human exposure. Moreover, there is a lack of information on the fate and behavior of copper-treated wood particles following oral ingestion. In this study, the in vitro bioaccessibility of copper from copper-treated wood dust in simulated stomach fluid and DI water was determined. Three copper-treated wood products, liquid alkali copper quaternary and two micronized copper quarternary from different manufacturers, were incubated in the extraction media then fractionated by centrifugation and filtration through 0.45 m and 10 kDa filters. The copper concentrations from isolated fractions were measured using Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES). Total amounts of copper from each wood product were also determined using microwave-assisted acid digestion of dried wood samples and quantification using ICP-OES. The percent in vitro bioaccessible copper was between 83 and 90 % for all treated wood types. However, the percent of copper released in DI water was between 14 and 25 % for all wood products. This data suggests that copper is highly bioaccessible at low pH and may pose a potential human exposure risk upon ingestion.
This dataset is associated with the following publication:
Santiago-Rodrigues, L., J.L. Griggs, K. Bradham , C. Nelson , T. Luxton , W. Platten , and K. Rogers. Assessment of the bioaccessibility of micronized copper wood in synthetic stomach fluid. Environmental Nanotechnology, Monitoring and Management. Elsevier B.V., Amsterdam, NETHERLANDS, 4: 85-92, (2015).
Resources
| Name |
Format |
Description |
Link |
|
10 |
Table%20S2.docx |
https://pasteur.epa.gov/uploads/277/Table%20S2.docx |
|
10 |
Table%20S3.docx |
https://pasteur.epa.gov/uploads/277/Table%20S3.docx |
Tags
- synthetic-stomach-fluid
- micronized-copper
- copper
- wood
- bioaccessibility
- human-exposure