Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization

Description

The supplemental information for this paper includes chemical-specific analytical methods, raw instrument data for chemical concentration analysis, processed data for experiments on intrinsic hepatic clearance (CLint -- metabolism) and chemical fraction unbound in the presence of human plasma protein (fup). Figures showing the curve fits for determining CLint are provided. Finally, all data were released publicly as HTTK R Package v1.10.1. This dataset is associated with the following publication: Wambaugh, J., B. Wetmore, C. Ring, C. Nicolas, R. Pearce, G. Honda, R. Dinallo, D. Angus, J. Gilbert, T. Sierra, A. Badrinarayanan, B. Snodgrass, A. Brockman, C. Strock, R. Setzer, and R. Thomas. Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization. TOXICOLOGICAL SCIENCES. Society of Toxicology, RESTON, VA, 172(2): 235-251, (2019).

Resources

Name Format Description Link
0 https://cran.r-project.org/package=httk
53 SupTable4-ProcessedData.xlsx https://pasteur.epa.gov/uploads/10.23719/1504435/SupTable4-ProcessedData.xlsx
53 SupTable1-AnalyticalMethods.xlsx https://pasteur.epa.gov/uploads/10.23719/1504435/SupTable1-AnalyticalMethods.xlsx
33 SupplementalFigures4.pdf https://pasteur.epa.gov/uploads/10.23719/1504435/SupplementalFigures4.pdf
53 SupTable3-RawCLintData.xlsx https://pasteur.epa.gov/uploads/10.23719/1504435/SupTable3-RawCLintData.xlsx
53 SupTable2-RawPPBData.xlsx https://pasteur.epa.gov/uploads/10.23719/1504435/SupTable2-RawPPBData.xlsx
0 https://www.epa.gov/chemical-research/toxicity-forecaster-toxcasttm-data

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  • exposure
  • expocast

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