An Audio Jack-Based Electrochemical Impedance Spectroscopy Sensor for Point-of-Care Diagnostics-Link to Data

Description

Portable and easy-to-use point-of-care (POC) diagnostic devices hold high promise for dramatically improving public health and wellness. In this paper, we present a mobile health immunoassay platform based on audio jack-embedded devices, such as smartphones and laptops, that uses electrochemical impedance spectroscopy to detect binding of target biomolecules. This platform is intended to be used as a plug-and-play peripheral that reuses existing hardware in the mobile device, and does not require an external battery, thereby improving upon its convenience and portability. Experimental data using a passive circuit network to mimic an electrochemical cell demonstrate that the device performs comparable to laboratory grade instrumentation with 0.3% and 0.5? magnitude and phase error, respectively, over a 17 Hz-17 kHz frequency range. The measured power consumption is 2.5 mW with a dynamic range of 60 dB. This platform was verified by monitoring the real-time formation of a NeutrAvidin self-assembled monolayer on a gold electrode demonstrating the potential for POC diagnostics.

Resources

Name Format Description Link
57 Portable and easy-to-use point-of-care (POC) diagnostic devices hold high promise for dramatically improving public health and wellness. In this paper, we present a mobile health immunoassay platform based on audio jack-embedded devices, such as smartphones and laptops, that uses electrochemical impedance spectroscopy to detect binding of target biomolecules. This platform is intended to be used as a plug-and-play peripheral that reuses existing hardware in the mobile device, and does not require an external battery, thereby improving upon its convenience and portability. Experimental data using a passive circuit network to mimic an electrochemical cell demonstrate that the device performs comparable to laboratory grade instrumentation with 0.3% and 0.5° magnitude and phase error, respectively, over a 17 Hz-17 kHz frequency range. The measured power consumption is 2.5 mW with a dynamic range of 60 dB. This platform was verified by monitoring the real-time formation of a NeutrAvidin self-assembled monolayer on a gold electrode demonstrating the potential for POC diagnostics. https://osf.io/xkun8/download

Tags

  • mhealth
  • audio-jack
  • point-of-care-testing
  • electrochemical-impedance-spectroscopy
  • electrochemical-sensors

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