Description
Acute-phase serum amyloid A (A-SAA) is a major component of the
acute-phase response. A sustained acute-phase response in rheumatoid arthritis
(RA) is associated with increased joint damage. A-SAA mRNA expression was
confirmed in all samples obtained from patients with RA, but not in normal
synovium. A-SAA mRNA expression was also demonstrated in cultured RA
synoviocytes. A-SAA protein was identified in the supernatants of primary
synoviocyte cultures, and its expression colocalized with sites of macrophage
accumulation and with some vascular endothelial cells. It is concluded that
A-SAA is produced by inflamed RA synovial tissue. The known
association between the acute-phase response and progressive joint damage may
be the direct result of synovial A-SAA-induced effects on cartilage
degradation.
Resources
| Name | Format | Description | Link |
|---|---|---|---|
| Official Government Data Source | HTML | Visit the original government dataset for complete information, documentation, and data access. | Open resource |