Description
Background
The EST database provides a rich resource for gene discovery and in silico expression analysis. We report a novel computational approach to identify co-expressed genes using EST database, and its application to IL-8.
Results
IL-8 is represented in 53 dbEST cDNA libraries. We calculated the frequency of occurrence of all the genes represented in these cDNA libraries, and ranked the candidates based on a Z-score. Additional analysis suggests that most IL-8 related genes are differentially expressed between non-tumor and tumor tissues. To focus on IL-8's function in tumor tissues, we further analyzed and ranked the genes in 16 IL-8 related tumor libraries.
Conclusions
This method generated a reference database for genes co-expressed with IL-8 and could facilitate further characterization of functional association among genes.
Resources
| Name | Format | Description | Link |
|---|---|---|---|
| Official Government Data Source | HTML | Visit the original government dataset for complete information, documentation, and data access. | Open resource |