A reference database for tumor-related genes co-expressed with interleukin-8 using genome-scale

Description

Background The EST database provides a rich resource for gene discovery and in silico expression analysis. We report a novel computational approach to identify co-expressed genes using EST database, and its application to IL-8. Results IL-8 is represented in 53 dbEST cDNA libraries. We calculated the frequency of occurrence of all the genes represented in these cDNA libraries, and ranked the candidates based on a Z-score. Additional analysis suggests that most IL-8 related genes are differentially expressed between non-tumor and tumor tissues. To focus on IL-8's function in tumor tissues, we further analyzed and ranked the genes in 16 IL-8 related tumor libraries. Conclusions This method generated a reference database for genes co-expressed with IL-8 and could facilitate further characterization of functional association among genes.

Resources

Name Format Description Link
21 Visit the original government dataset for complete information, documentation, and data access. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC131052/

Tags

  • tumor-genes
  • gene-co-expression
  • nih
  • cancer-research
  • interleukin-8

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