A new non-linear normalization method for reducing variability in DNA microarray experiments

Description

A simple and robust non-linear method is presented for normalization using array signal distribution analysis and cubic splines. Both the regression and spline-based methods described performed better than existing linear methods when assessed on the variability of replicate arrays

Resources

Name Format Description Link
21 Visit the original government dataset for complete information, documentation, and data access. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC126873/

Tags

  • data-normalization
  • nih
  • variability-reduction
  • cubic-splines
  • dna-microarray

Topics

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