Description

This study investigated the effects of two short-chain per- and polyfluoroalkyl substances (PFAS): perfluorobutane sulfonamide (FBSA) and 5:3 fluorotelomer carboxylic acid (5:3 FTCA), on fathead minnows (Pimephales promelas). Chronic morphometric and behavioural effects were evaluated throughout the exposure. Embryos were exposed to a concentration gradient ranging from 0 to 10 000 nanograms per litre (ng/L) and were under exposure conditions until 16 days post-hatch (dph). Assessed endpoints included hatchability, time-to-hatch, larval deformities, growth, and survival. Behavioural responses were measured by exposing 9 dph fry to alternating light and dark stimuli and quantifying activity and movement. A PFAS mixture of six compounds will also be tested in the future. The body burden of PFAS in these exposed fish will subsequently be measured to determine whether fathead minnows sequester and/or degrade these compounds. The findings from this study will support risk assessors in developing guidelines for the use and regulation of these PFAS compounds in industrial applications. Supplemental Information The Chemicals Management Plan (CMP) is a Government of Canada initiative aimed at reducing the risks posed by chemicals to Canadians and their environment. A key element of the Chemicals Management Plan is the monitoring and surveillance of levels of harmful chemicals in Canadians and their environment. Monitoring and surveillance are essential to identify and track exposure to hazards in the environment and associated health implications. Monitoring and surveillance programs provide the basis for making sound and effective public health and environmental health policies and interventions, as well as measuring the efficacy of control measures. In support of the Chemicals Management Plan, monitoring and surveillance initiatives were established to support Health Canada and Environment and Climate Change Canada scientists, in collaboration with external partners and researchers, to advance our knowledge. This initiative has allowed the Government of Canada to increase its commitment to a number of existing monitoring initiatives, as well as to support new efforts. For more information on the Chemicals Management Plan, please visit https://www.canada.ca/en/health-canada/services/chemical-substances/chemicals-management-plan.html

Resources

Name	Format	Description	Link
CMP-PF~1	CSV		https://data-donnees.az.ec.gc.ca/api/file?path=%2Fsubstances%2Fassess%2Ffathead-minnow-21-day-exposure-PFAS-chemicals-mixture%2FCMP-PF~1.CSV
CMP-PF~2	CSV		https://data-donnees.az.ec.gc.ca/api/file?path=%2Fsubstances%2Fassess%2Ffathead-minnow-21-day-exposure-PFAS-chemicals-mixture%2FCMP-PF~2.CSV
View ECCC Data Mart (English)	HTML		https://data-donnees.az.ec.gc.ca/data/substances/assess/fathead-minnow-21-day-exposure-PFAS-chemicals-mixture?lang=en
View ECCC Data Mart (French)	HTML		https://data-donnees.az.ec.gc.ca/data/substances/assess/fathead-minnow-21-day-exposure-PFAS-chemicals-mixture?lang=fr

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